Taking images of tiny structures within cells is tricky business. One technique, cryogenic electron tomography (cryoET), shoots electrons through a frozen sample. The images formed by the electrons ...

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...

Researchers identify altered expression of genes that worsens periodontitis among smokers, and a new target molecule ...

Scientists can peer into cells to get a limited view of their activity using microscopes and other tools. However, cells and ...

Scientists first read the human genome, a three-billion-letter biological book, in April 2003. Since then, researchers have steadily advanced the ability to write DNA, moving far beyond single-gene ...

Learn how AI is transforming predictions of drug-induced liver injury and aiding drug development for safer therapeutics.

Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited efficacy of current therapies in advanced cases. As a key risk factor for HCC, liver ...

The partners are launching ImmuneScape, a multiomics program using spatial and single-cell sequencing to study immune drivers ...

Research led by the SickKids Research Institute in Toronto and the University of Pennsylvania, has found that immune-related ...

The final, formatted version of the article will be published soon. Hepatocellular carcinoma (HCC) is characterized by pronounced intratumoral heterogeneity and a complex immune microenvironment, ...

Sensorineural hearing loss (SNHL) is a highly prevalent sensory disorder globally, affecting over 1.5 billion people, with a ...

The largest single cell perturbation dataset to-date will be generated and released open source in a new team effort.