Five signaling subtypes identified by NMF clustering. Subtype 5 (high APsig) correlates with immune-rich "hot" tumors, while Subtype 2 (low APsig) exhibits metabolic reprogramming and hypoxia. High ...

A new University of California San Diego School of Medicine study offers a unified biological model to explain how genetic predispositions and environmental exposures converge to cause autism spectrum ...

The NF-κB transcription factor plays a critical role in regulating cell growth, cell survival and the response to stress. The activity of NF-κB is controlled by three inhibitory IκB isoforms (IκBα, -β ...

A new University of California San Diego School of Medicine study offers a unified biological model to explain how genetic predispositions and environmental exposures converge to cause autism spectrum ...

For years, scientists have struggled to connect the diverse genetic and environmental factors associated with autism into a single coherent explanation. Now, a researcher at the University of ...