BMJ

Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study

Background Prostate cancer (PCa) is the most common male malignancy in the western world. Many men (40%) are diagnosed with localised low or intermediate-risk PCa, which is suitable for active ...
Journal of Medical Internet Research

Social-Media-Based Mental Health Interventions: Meta-Analysis of Randomized Controlled Trials

Objective: To address this gap, we conducted a pre-registered meta-analysis to synthesize findings from rigorously designed randomized controlled trials (i.e., low attrition, comparable baseline ...
Journal of Medical Internet Research

Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes ...

This review included randomized controlled trials (RCTs) that studied the effectiveness of lifestyle interventions in adults with prediabetes. The overall intervention effect was synthesized using a ...
BMJ

Exploratory treatment trials in multiple sclerosis using MRI: sample size calculations for relapsing-remitting and secondary progressive subgroups using placebo controlled ...

Professor DH Miller, NMR Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK. Telephone 0044 171 837 3611; fax 0044 171 278 5616. OBJECTIVES Serial brain MRI is widely used in pilot ...
BMJ

Shared decision-making using a decision aid for patients with breast cancer considering breast reconstruction: study protocol for a cluster-randomised controlled trial in Japan

Introduction Shared decision-making (SDM) requires that individuals are correctly and smoothly supported to make decisions. However, in Japan, development of decision aids (DAs) to support ...
UroToday

A Systematic Review on Power Estimation and Sample Size Calculation in Randomized Controlled Trials of Surgical Treatments for Benign Prostatic Hyperplasia.

Randomized controlled trials (RCTs) are considered the gold standard for evaluating surgical interventions for benign prostatic hyperplasia (BPH). However, the validity and reliability of their ...