Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have ...

– 53.7% mean splicing correction observed following a single 15 mg/kg dose of PGN-EDODM1, with all patients showing an improvement in splicing – – PGN-EDODM1 was generally well-tolerated at 15 mg/kg, ...

The latest study from the Sharma Lab at UC Santa Cruz makes the mechanisms of how epigenetic information is established in sperm cells, and how that encoding affects offspring health, a little less of ...

La Jolla Labs was founded to make modern RNA biology and advanced computational techniques directly useful to patients whose ...

Abstract: The subcellular localization of messenger RNA (mRNA) is essential for the regulation of gene expression and plays a pivotal role in targeted drug development. Although several computational ...

New research provides a mechanistic map of how genetic mutations disrupt RNA splicing in acute myeloid leukemia.

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic mutations – IDH2 and SRSF2 – work cooperatively to mis-splice RNA messages ...

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic ...

A new research paper featured as the cover of Volume 17, Issue 12 of Aging-US was published on December 22, 2025, titled "A combination of differential expression and network connectivity analyses ...

The cover of Aging-US Volume 17, Issue 12, features Figure 5 from the research paper, titled "A combination of differential expression and network connectivity analyses identifies a common set of RNA ...

Abstract: MiRNA subcellular localizations (MSLs) are essential for uncovering and understanding miRNA functions in various biological processes. Several computational methods have been proposed for ...