The fact that the complement system is activated during immune-complex glomerular disease has been known for nearly 50 years. Detection of complement deposition in the glomerulus using immunochemistry ...

How would you treat a 30-year-old woman with systemic lupus erythematous (SLE) and lupus nephritis (LN) class 3 with new ...

Medically reviewed by Jamin Brahmbhatt, MD Key Takeaways Complement 3 glomerulopathy (C3G) is diagnosed with a combination of ...

Anyone can get lupus, no matter their age or sex. But it’s less common for men to get lupus, with about 1 in every 10 cases happening in men. Experts still aren’t sure exactly why. Learn more about ...

Persistent hematuria in patients diagnosed with lupus nephritis independently predicts adverse outcomes. Patients who have hematuria at lupus nephritis (LN) diagnosis that does not improve but rather ...

Medically reviewed by Erika Prouty, PharmD Key Takeaways There are two types of complement 3 glomerulopathy: dense deposit ...

Full results from the first phase 3 trial of UCB and Biogen's anti-CD40L antibody dapirolizumab pegol (DZP) in systemic lupus erythematosus (SLE) have been revealed, and have not disappointed.

Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure (1). In ∼90% of childhood cases, HUS follows a ...