Nature

Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

Protein disulfide isomerase (PDI), secreted by platelets and endothelial cells on vascular injury, is required for thrombus formation. Using PDI variants that form mixed disulfide complexes with their ...
Business Wire

Biological Industries USA Adds Vitronectin XF™ to its Stem Cell Portfolio Through Agreement with Primorigen Biosciences, Inc.

CROMWELL, Conn. & MADISON, Wis.--(BUSINESS WIRE)--Biological Industries USA (BI-USA), a division of Biological Industries Beit Haemek Israel (BI), and Primorigen Biosciences, Inc. announce a strategic ...
News Medical

Scientists discover promising drug target for dry age-related macular degeneration

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that the blood protein vitronectin is a promising drug target for dry age-related macular degeneration (AMD), a leading ...
JSTOR Daily

Protein Kinase C-Dependent Effects of 12(S)-HETE on Endothelial Cell Vitronectin Receptor and Fibronectin Receptor

12(S)-HETE, a lipoxygenase metabolite of arachidonic acid induced a nondestructive and reversible endothelial cell (EC) retraction. 12(S)-HETE induced EC retraction was inhibited by protein kinase C ...
Nature

Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration

There is evidence for complement dysfunction in age-related macular degeneration (AMD). Complement activation leads to formation of the membrane attack complex (MAC), known to assemble on retinal ...