Tertiary lymphoid structures (TLS) are ectopic cellular hubs that coordinate immunity within patient tumors. TLS also correlate with improved prognosis and superior response to immunotherapy. While ...

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign ...

Please provide your email address to receive an email when new articles are posted on . A machine learning model may aid the detection and classification of tertiary lymphoid structures associated ...

TLSs are highly organized structures that typically appear as clusters of B-cells containing FDCs. These clusters are then surrounded by T-cells and HEVs as shown schematically in Figure 1. We ...

Novel Model Integrating TME Composition with TLS Gene Signatures Predicts Meaningful Survival Differences in Checkpoint Inhibitor-Treated Patients Cellworks Group Inc., a leader in Personalized ...

A team led by surgeon-scientist Dr. Vinod Balachandran identified the molecular pathway involved in the formation of tertiary lymphoid structures. Therapeutically targeting this pathway could ...

Gene modules in association with Kaiso and LC3 regulatory pathways to predict survival and response to therapy. This is an ASCO Meeting Abstract from the 2022 ASCO Annual Meeting I. This abstract does ...

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures ...

Advances in cancer immunotherapy suggest that tumor-infiltrating lymphocytes (TILs) are critical for the elimination of tumor cells and maintenance of effective immunosurveillance. Spatial phenotyping ...