Peripheral sensitization refers to the lowering of the threshold of excitability of sensory neurons, which leads to an amplified reaction to a specific external stimulus. Sensitization can be mediated ...

Neuropathic pain arises directly from a lesion or disease affecting the somatosensory system. Our current knowledge on the mechanisms of neuropathic pain comes largely from animal models of peripheral ...

Despite extensive research, the pathogenesis of pain in fibromyalgia syndrome is incompletely understood. Fibromyalgia pain is consistently felt in deep tissues including ligaments, joints and muscles ...

Pain represents the cardinal symptom of osteoarthritis, yet its intensity, quality, and impact vary dramatically among ...

There are the unfortunate patients who develop pain hypersensitivity. These patients have a pain threshold that is lower than normal, and the duration of the pain response can become long-lived. There ...

Neuropathic pain poses a huge burden on public health and significantly affects quality of life. Yet the current therapies are often inadequate. Therefore, there is an urgent need for a better ...

—Unraveling the pathways and risk determinants involved in the transition from acute to chronic pain is crucial for developing effective intervention strategies that can prevent, manage, or even cure ...